Lisa Little holds a Master of Architecture from the Southern California Institute of Architecture (SCI-Arc) and a Bachelor of Science in electrical engineering from Georgia Institute of Technology. Little integrates her engineering and architecture backgrounds to create an atypical approach to research and design. Her work strives to engage ambient phenomena through built form while questioning the role of technology in contemporary architectural practice. She is the principal and founder of the award-winning firm Vertebrae.

Recent projects include large scale artworks, commercial interiors, and private residences. The work has been widely published and exhibited, appearing in the LA Times, Interior Design Magazine, The California Design Biennial and numerous museums, galleries, and books. Before founding Vertebrae, Little co-founded the design practice Layer, an interdisciplinary design firm. She has also worked as the director of software development teams and as a hardware design engineer in the field of film and television postproduction. Little currently teaches graduate and undergraduate level design studios at the University of Southern California and is a licensed architect in the state of California.